于辉

• 1:郑州大学第一附属医院心内科 河南郑州450052

摘要(Abstract)：

关键词(KeyWords)：

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 于辉

参考文献(References)：

• [1]Moncada Sk,Higgs A.The L_arginine_nitric oxide pathway[J].N Engl JMed,1993,329(27):2002_2012.
• [2]Seielstad MT,Minch E,Cavalli_Sforza LL.Genetic evidence for a higherfemale migration rate in humans[J].Nat Genet,1998,20(3):278_280.
• [3]Marsden PA,Heng HH,Scherer SW,et al.Structure and chromosomal lo-calization of the human constitutive endothelial nitric oxide synthase gene[J].J Biol Chem,1993,268(23):17478_17488.
• [4]Yoshimura M,Yasue H,Nikayama M,et al.Amissense Glu298 Asp variantin the endothelial nitric oxide synthase gene is associated with coronaryspasm in the Japanese[J].Hum Genet,1998,103(1):65.
• [5]Wei D,Shan J,Chen Z,et al.The G894T mutation of the endothelial nitricoxide synthase gene is associated with coronary atherosclerotic heart diseasein Chinese[J].Zhonghua Yi Xue Yi Chuan Xue Za Zhi,2002,19(6):471_474.
• [6]Hingorani AD,Liang CF,Fatibene J,et al.A common variant of the en-dothelial nitric oside synthase(Glu298_Asp)is a major risk factor for coro-nary artery disease in the UK[J].Circulation,1999,100(14):1515.
• [7]Colombo MG,Andreassi MG,Paradossi U,et al.Evidence for association ofa common variant of the endothelial nitric oxide synthase gene(Glu_Asp-polymorphism)to the presence,extent and severity of coronary artery dis-ease[J].Heart,2002,87(6):525_528.
• [8]Afrasyap L,Ozturk G.NO level and endothelial NO synthase gene polymor-phism(Glu298Asp)in the patients with coronary artery disease from theTurkish population[J].Acta Biochim Biophys Sin(Shanghai),2004,36(10):661_666.
• [9]Spene MS,McGlinchey PG,Patterson CC,et al.Endothelial nitric oxidesynthase gene polymorphism and ischemic heart disease[J].Am Heart J,2004,148(5):847_851.
• [10]Poirier O,Mao C,Mallet C,et al.Polymorphism of the endothelial nitric ox-ide synthase gene no consistent association with myocardial infarction in theECTIM study[J].Eur J Clin Invest,1999,29(4):284.
• [11]Wang XL,Sim SA,Badenhop RF,et al.A smoking_dependent risk of coro-nary artery disease associated with a polymorphism of the endothelial nitricoxide synthase gene[J].Nat Med,1996,2(1):41_45.
• [12]Ichihara S,Yamada Y,Fujimura T.Association of a polymorphism of theendothelial constitutive nitric oxide synthase gene with myocardial infarctionin the Japanese population[J].The American Journal of Cardiology,1998,81(1):83_86.
• [13]Rao S,Austin H,Davidoff MN,et al.Endothelial nitric oxide synthase in-tron 4 polymorphism is a marker for coronary artery disease in African_American and Caucasian men[J].Ethn Dis,2005,15(2):191_197.
• [14]Matyar S,Attila G,Acarturk E,et al.Enos gene intron 4 a/b VNTR poly-morphism is a risk factor for coronary artery disease in Southern Turkey[J].Clin Chim Acta,2005,354(1_2):153_158.
• [15]Yoon S,Shin C,Park HY,et al.Endothelial nitric oxide synthase gene isassociated with vessel stenosis in Korean population[J].Clin Chim Acta,2005,353(1_2):177_185.
• [16]Nakayama M,Yasue H,Yoshimura M,et al.T(_786)_(C mutation in the 5(_flanking region of the endothelial nitric oxide synthase gene is associatedwith myocardial infarction,especially without coronary organic stenosis[J].Am J Cardiol,2000,15,86(6):628_634.
• [17]Nakayama M,Yoshimura M,Sakamoto T,et al.Synergistic interaction of T(_786)_(C polymorphism in the endothelial nitric oxide synthase gene andsmoking for an enhanced risk for coronary spasm[J].Pharmacogenetics,2003,13(11):683_688.
• [18]Colombo MG,Paradossi U,Andreassi MG,et al.Endothelial nitric oxidesynthase gene polymorphism and risk of coronary artery disease[J].ClinChem,2003,49(3):389_395.
• [19]T(_786)_〉(C promoter allelic polymorphism of endothelial NO_synthasegene as genetic predictor of acute coronary syndrome[J].Fiziol Zh,2005,51(1):72_76.
• [20]Yoshimura M,Yasue H,Nakayama M,et al.Genetic risk factors for coro-nary artery spasm:significance of endothelial nitric oxide synthase geneT786_C and missense Glu298Asp variants[J].J Investig Med,2000,48(5):367_374.
• [21]Alvarez R,Gonzalez P,Batalla A,et al.Association between the NOS3(_786T/C)and the ACE(I/D)DNA genotypes and early coronary artery dis-ease[J].Nitric Oxide,2001,5(4):343_348.
• [22]Maria Giovanna Colombo,Umberto Paradissi,Maria Grazia Andreassi,etal.Endothelial nitric oxide synthase gene polymorphism and risk of coronafyartery disease[J].Clinical Chemistry,2003,49(3):389_395.
• [23]Gramath B,Taylor R,van Bockxmeer,et al.Lack of evidence for associa-tion between endothelial nitric oxide synthase gene polymorphisms andcoronafy artery disease in the Australian Caucasian population[J].Journalof Cardiovascular Risk,2001,8(4):235_241.
• [24]Yoon S,Shin C,Park HY,et al.Endothelial nitric oxide synthase gene isassociated with vessel stenosis in Korean population[J].Clin Chim Acta,2005,353(1_2):177_185.